If you’re looking into testosterone therapy, you’ve probably heard about anastrozole, clomiphene, and enclomiphene.
And like most guys, you’ve probably thought:
“Okay, cool… but which one is actually right for me?”
Let’s make this simple, clear, and no-BS.
Anastrozole (Arimidex)
“The Estrogen Stopper”
This medication blocks your body from converting testosterone into estrogen.
Sounds great at first… until you realize:
Your body actually needs some estrogen for:
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Joint comfort
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Bone strength
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Mood balance
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Sexual performance and desire
When it helps:
Short-term use if estrogen gets noticeably high during TRT
When it causes issues:
Long-term use can make you feel:
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Stiff / achy
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Flat emotionally
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Low libido
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Just… not yourself
Our take:
Useful as a precision tool, not a daily habit.
Clomiphene (Clomid)
“The Fertility Protector (with some caveats)”
Clomid stimulates your own testosterone production.
It also supports sperm production, which makes it a strong option for men who want kids now or in the future.
But here’s the catch:
Some guys feel great on it.
Some guys… don’t.
Possible side effects:
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Mood swings
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Head pressure/headaches
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Rare visual disturbances (floaters / flashes)
Our take:
A solid tool — if your mood stays stable on it.
Enclomiphene
“Clomid’s Smarter, Cleaner Cousin”
Clomid contains two parts:
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One part that raises testosterone (good)
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One part that causes side effects (not good)
Enclomiphene removes the side that causes the problems.
Why guys tend to like it:
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Boosts testosterone naturally
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Maintains sperm count + testicular volume
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Helps keep estrogen balanced
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Generally fewer mood or vision side effects
Our take:
For men who want to boost testosterone, protect fertility, and still feel emotionally level — this is often the win.
Quick Comparison:
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Anastrozole: Best as a short-term estrogen control tool — not meant for long-term daily use.
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Clomiphene: Good for raising testosterone while protecting fertility, but mood/vision effects vary.
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Enclomiphene: Gives the same fertility benefits as Clomid, but typically feels smoother and more consistent.
So What Do We Recommend?
We don’t guess — we tailor.
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Trying to stay fertile? → We usually lean Enclomiphene
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Just need to calm estrogen down temporarily? → Short-term Anastrozole
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Want a natural boost without starting injectable TRT? → Enclomiphene is usually the move
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Clomid still has a place — we just use it thoughtfully
There’s no award for being on the most meds.
There’s only feeling good long-term.
Your Next Step
If you’re wondering which approach fits your body, your goals, and your life:
We make this simple, precision-based, and actually human.
Call/Text: (303) 725-0474
Reach out to us via our contact form for more information.
Equivalence Wellness
Precision Hormone Care Designed for Real Life.
Steve Dillenbeck
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